Botulinum toxin type a
Nuceiva (botulinum toxin type a) is a protein pharmaceutical. Botulinum toxin type a was first approved as Nuceiva on 2019-09-27. It is used to treat blepharospasm, dystonia, fissure in ano, genetic skin diseases, and muscle rigidity amongst others in the USA. It has been approved in Europe to treat skin aging.
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle spasticity | D009128 | — | — | 9 | 19 | 46 | 26 | 80 | 172 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 8 | 18 | 26 | 29 | 35 | 110 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 6 | 11 | 29 | 15 | 40 | 96 |
| Cerebral palsy | D002547 | — | G80 | 3 | 10 | 22 | 7 | 48 | 86 |
| Dystonia | D004421 | — | — | 6 | 13 | 15 | 13 | 31 | 73 |
| Torticollis | D014103 | — | F45.8 | 5 | 12 | 13 | 13 | 26 | 67 |
| Dystonic disorders | D020821 | — | G24 | 6 | 12 | 15 | 11 | 27 | 66 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 3 | 9 | 15 | 14 | 24 | 62 |
| Syndrome | D013577 | — | — | 14 | 26 | 10 | 5 | 11 | 57 |
| Urinary incontinence | D014549 | — | R32 | 4 | 7 | 15 | 12 | 10 | 44 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Traumatic brain injuries | D000070642 | — | S06 | — | 4 | 5 | — | 5 | 13 |
| Sialorrhea | D012798 | — | K11.7 | — | 5 | 9 | — | 2 | 13 |
| Equinus deformity | D004863 | — | — | — | 1 | 1 | — | 8 | 10 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | 1 | 2 | 1 | — | 5 | 9 |
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | — | — | 5 | — | 4 | 9 |
| Talipes | D000070558 | — | Q66.1 | — | 1 | 1 | — | 7 | 9 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 3 | 5 | 2 | — | 1 | 8 |
| Dysphonia | D055154 | — | R49.0 | 2 | 3 | 1 | — | 4 | 7 |
| Hoarseness | D006685 | — | R49.0 | 2 | 3 | 1 | — | 4 | 7 |
| Ganglion cysts | D045888 | — | M67.4 | 2 | 4 | 2 | — | 1 | 7 |
Show 69 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle cramp | D009120 | — | — | 1 | 3 | — | — | 3 | 6 |
| Contracture | D003286 | EFO_0003899 | M62.4 | — | 2 | — | — | 3 | 5 |
| Myalgia | D063806 | — | M79.1 | — | 1 | — | — | 2 | 3 |
| Abdominal hernia | D046449 | — | K46 | — | 1 | — | — | 2 | 3 |
| Internal hernia | D000082122 | — | — | — | 1 | — | — | 2 | 3 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | 2 | 3 |
| Neck pain | D019547 | — | M54.2 | 2 | 1 | — | — | 1 | 3 |
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | — | 3 | — | — | — | 3 |
| Prostatic neoplasms | D011471 | — | C61 | 2 | 1 | — | — | — | 3 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 3 | — | — | — | 3 |
Show 73 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhagic stroke | D000083302 | — | — | 1 | — | — | — | 2 | 3 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | 1 | — | — | — | 2 | 3 |
| Reflex sympathetic dystrophy | D012019 | EFO_1001147 | G90.5 | 1 | — | — | — | 2 | 3 |
| Neurologic gait disorders | D020233 | — | R26.1 | 1 | — | — | — | 1 | 2 |
| Skin abnormalities | D012868 | — | Q82.9 | 1 | — | — | — | 1 | 2 |
| Intracranial sinus thrombosis | D012851 | — | — | 1 | — | — | — | — | 1 |
| Internal carotid artery dissection | D020215 | — | — | 1 | — | — | — | — | 1 |
| Vertebral artery dissection | D020217 | — | I77.74 | 1 | — | — | — | — | 1 |
| Vascular headaches | D014653 | — | — | 1 | — | — | — | — | 1 |
| Bursitis | D002062 | EFO_1000941 | M71.9 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 2 | 2 |
| Movement disorders | D009069 | EFO_0004280 | G25 | — | — | — | — | 2 | 2 |
| Gingival recession | D005889 | — | K06.0 | — | — | — | — | 2 | 2 |
| Pancreatectomy | D010180 | EFO_0002581 | — | — | — | — | — | 1 | 1 |
| Treatment outcome | D016896 | — | — | — | — | — | — | 1 | 1 |
| Muscle tonus | D009129 | — | — | — | — | — | — | 1 | 1 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | — | — | 1 | 1 |
| Physical therapy modalities | D026741 | — | — | — | — | — | — | 1 | 1 |
| Anticholinergic syndrome | D064807 | — | — | — | — | — | — | 1 | 1 |
| Erythema | D004890 | — | L53.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Botulinum toxin type a |
| INN | — |
| Description | Botulinum toxin, or botulinum neurotoxin, is a highly potent neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism. The toxin is also used commercially for medical and cosmetic purposes.
|
| Classification | Neurotoxin |
| Drug class | fluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297862 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00083 |
| UNII ID | — |
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4,113 adverse events reported
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